Life sciences companies – key contributors to the healthcare ecosystem – are challenged to evolve continually by obtaining new skills, building new technology systems, and delivering more value to patients and other stakeholders, all while acting more efficiently and rapidly. Every few years, changes in the healthcare ecosystem drive a new set of needs. The impact of advancements in human science, technology, and data science, combined with the impact of the pandemic, have increased the urgency of this transformation and have made a new set of competencies — that of connected intelligence — essential. For life sciences companies, building connected intelligence enables them to make better decisions, share insights with stakeholders collaboratively, and act agilely in an increasingly competitive environment. However, building connected intelligence will impact the data they use, the talent they hire, and the technology they build.